Respiratory Syncytial Virus (RSV) Infection

Patient Presentation
A 6 month old female, E.C., presents to the ER with her parents in January with rhinorrhea, cough, wheezing and a low-grade fever of 37.5 degrees Celsius. Upon initial assessment, the RN notices E.C. to have a slight increased work of breathing, mild fussiness and pallor. E.C.’s parents complain of her having upper respiratory tract symptoms and decreased oral intake over the last 2-3 days. E.C.’s history is positive for prematurity of 35 weeks. As E.C.’s stay in the ER continues, her respiratory status starts to deteriorate. She becomes tachypneic (RR of 70 breaths per minute) and her SaO2 drops to 90% on room air. In the ER, they put E.C. on 2 liters of oxygen via a nasal cannula, place an IV, start fluids, and transfer her to the PICU.  E.C. presents to the PICU with mild to severe retractions, wheezing, and cyanosis. Her temperature has increased to 38.5 degrees Celsius, she is tachycardic, her BP is stable, her SaO2 has dropped to the mid 80s even with supplemental O2, and her capillary refill is >2seconds. She is started on IV fluids of D5 0.45 NaCl but E.C. does not tolerate other forms of oxygen administration such as a face mask and the decision is made to intubate the child to prevent respiratory arrest. After a successful intubation, labs are drawn, CXR is completed and cultures are collected. (Many times we do not collect labs prior to intubating a child if we do not have proper access for fear of agitating the patient more and causing a more rapid deterioration in respiratory status).

Differential Diagnoses

Tests & Diagnosis

Treatment
The treatment for a child with RSV is mainly supportive. In E.C.’s case, a dose of the antibiotic vancomycin was administered due to a possible infection/sepsis but was discontinued once RSV results were positive. E.C. continued to receive mechanical ventilation support, frequent P&PD (percussion and postural drainage), IV hydration which was transitioned to post-pyloric tube feedings for nutrition after 24 hours. She received scheduled albuterol treatments (a bronchodilator – selective beta2-agonist that causes bronchial smooth muscle relaxation) via the ventilator to help open her airway and allow for more secretions to be suctioned. Mechanical ventilator adjustments were made as necessary as E.C.’s respiratory status improved. She was also on continuous sedation and pain medications to keep her comfortable while intubated.         

Outcome
E.C. remained intubated for 7 days as she received supportive therapy. Due to her improvement in ventilator settings, she was extubated on day 8 to 2 liters nasal cannula, she was weaned off of O2 with no desaturation and allowed to start a clear diet on day 9. On day 10, E.C. was transferred to the pediatric acute care floor before being transferred home. E.C.’s parents were instructed to consult with a pulmonologist regarding E.C.’s pulmonary function due to some studies that link RSV with possible reactive airway disease.